Molecular Themes in DNA ReplicationLynne Suzanne Cox Royal Society of Chemistry, 2009 - 443 sivua "Molecular Themes in DNA Replication highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. Exciting potential drug targets in DNA replication are discussed, particularly in the context of novel treatments for malaria and cancer." "Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities. The emphasis on mechanisms and the relationship between structure and function targets the chapters towards biochemists and biological chemists as well as molecular and cell biologists." --Book Jacket. |
Sisältö
Acknowledgements | xvii |
Conserved Steps in Eukaryotic DNA Replication | 1 |
Ring Structures and Sixfold Symmetry in | 47 |
Acknowledgements | 69 |
The Action of AAA+ ATPases in Loading Replication | 76 |
Mechanisms for High Fidelity DNA Replication | 86 |
Coordination of Nucleases and Helicases during | 112 |
Importance of Exo1 | 121 |
Coping with DNA Damage and Replication Stress | 178 |
Telomeres and the End Replication Problem | 217 |
9 | 269 |
Replication of Chromatin | 297 |
Mitochondrial DNA Replication | 316 |
a Paradigm | 346 |
DNA Replication in the Human Malaria Parasite | 363 |
223 | 388 |
Molecular Handoff Mechanisms in DNA Replication | 156 |
Replicative DNA Polymerases | 166 |
References | 172 |
Drug Targets in DNA Replication | 393 |
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Yleiset termit ja lausekkeet
Acad archaeal assembly ATPase Biochem C-terminal cancer catalytic Cdc6 Cell Biol cell cycle cell nuclear antigen Chapter checkpoint Chem chromatin chromosome cohesin cohesion condensin conserved Curr deletion dimer DNA damage DNA polymerase DNA repair DNA replication DNA synthesis Dna2 domain double-strand EMBO enzyme eukaryotic exonuclease factor FEN1 Figure flap function G-quadruplex Genes Dev Genet genome helicase activity histone homologous human cells human telomerase inhibition interaction kinase lagging strand lesions ligase loading mammalian MCM2-7 complex MCM4 mechanism mitochondrial DNA molecular molecules motif mtDNA mutations Natl nuclease Nucleic Acids Res nucleosome nucleotide Okazaki fragment pathway PCNA phosphorylation primase primer Proc processing recombination recruitment region regulation replication fork replication origins replication protein replisome residues reviewed in ref role Saccharomyces cerevisiae separase sequence Sgs1 single-stranded sister chromatid ssDNA stalled substrate subunits target telomerase RNA telomere template transcription translesion vitro vivo yeast