Skeletal Muscle Repair and Regeneration

Etukansi
Stefano Schiaffino, Terence Partridge
Springer Science & Business Media, 18.1.2008 - 379 sivua

Skeletal muscle is the most abundant tissue of our body. Apart from its essential role in locomotion, it is also the body’s main store of carbohydrate and protein as well as being one of the principal generators of heat. Its proper maintenance and function are, therefore, essential. A severe acute loss of muscle function is potentially lethal and the debilitating effects of chronic decline in mobility are commonplace experience, so repair and maintenance of the tissue must by both rapid and effective. Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. The topics range from correlation of changes in pattern of gene expression with the histological sequence during a regenerative episode to the distinctive insult-specific patterns of structural and functional outcome at the other end of the spectrum. The middle ground – who is doing what in this complex process – constitutes the meat of this sandwich.

 

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Sisältö

MYOGENESIS THE EARLY YEARS
1
THE ORIGIN AND GENETIC REGULATION OF MYOGENIC CELLS FROM THE EMBRYO TO THE ADULT
18
THE MUSCLE SATELLITE CELL THE STORY OF A CELL ON THE EDGE
45
NON MUSCLE STEM CELLS AND MUSCLE REGENERATION
65
TRANSCRIPTIONAL CASCADES IN MUSCLE REGENERATION
85
THE INS AND OUTS OF SATELLITE CELL MYOGENESIS THE ROLE OF THE RULING GROWTH FACTORS
107
RELAYING THE SIGNAL DURING MYOGENESIS INTRACELLULAR MEDIATORS AND TARGETS
144
MUSCLE REGENERATION IN ANIMAL MODELS
163
MUSCLE FIBRE REGENERATION IN HUMAN SKELETAL MUSCLE DISEASES
198
SKELETAL MUSCLE REPAIR AFTER EXERCISEINDUCED INJURY
217
INFLAMMATION IN SKELETAL MUSCLE REGENERATION
243
COMPLEXITY OF EXTRACELLULAR MATRIX AND SKELETAL MUSCLE REGENERATION
269
INNERVATION OF REGENERATING MUSCLE
302
BOOSTING MUSCLE REGENERATION
335
AGEDEPENDENT CHANGES IN SKELETAL MUSCLE REGENERATION
359
INDEX
375

SKELETAL MUSCLE RECONSTITUTION DURING LIMB AND TAIL REGENERATION IN AMPHIBIANS TWO CONTRASTING MECHANISMS
181

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