Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms
Iron plays a crucial role in many biochemical processes. In recent years intensive research has led to a better understanding of the function of iron in cellular metabolism. In more than twenty articles internationally renowned experts give a thorough account of the recent developments of this fascinating field. The book focuses on the central questions, e.g. transport, storage, and utilization of iron in cells, the three-dimensional structure of iron-containing proteins, the physiological function of heme and iron sulfur-containing proteins, and the regulatory mechanisms in heme biosynthesis and redox regulation of signal transduction.
The interdisciplinary character of the book is designed to explore the many facets of the new findings and to provide a comprehensive overview of recent advances for biochemists, bioinorganic chemists, molecular biologists, microbiologists and immunologists. The reviews are supplemented with valuable background information, results and numerous references. This book emphasizes the relationships between the different disciplines concerned with iron metabolism and opens new perspectives for future research!
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Acad aconitase activity ALAS2 amino acid anaerobic atoms bacterial binding Biochem Biochemistry Biol Biophys calcineurin catalytic cells cellular Chem cluster cofactor coli complex coordination cysteine cytochrome c peroxidase cytochrome P450 diferrous diiron dimer dinuclear dioxygen domain DtxR E. C. Theil EcBfr EcFtna electron transfer enzyme Fe(II Fe2+ ferric ferritin ferrochelatase ferrous ferroxidase Fet3p Figure ﬁrst function gene glycine heme heme—hemopexin hemopexin HO-l HP heme HuHF identiﬁed interactions intermediate iron transport IRP2 IRPl ligands M. W. Hentze mechanism metabolism metal ions MMOH molecular molecule Mossbauer mRNA mutant Natl oxidase oxidative stress oxygen P. M. Harrison pathway peroxidase porphyrin Proc puriﬁed purple acid phosphatase R. D. Klausner radical reaction receptor redox reduced reductase regulation regulatory residues role rubredoxin S. J. Lippard sequence signal signiﬁcant species speciﬁc spectroscopic structure studies substrate subunit T. A. Rouault transcription transferrin wild-type