Handbook of Pharmaceutical Granulation Technology
Integrating the basic principles and industrial practices of pharmaceutical granulation production, this book discusses technologies and demonstrates cost-effective approaches to manufacturing solid-dosage forms with content uniformity and consistent physical properties while complying with regulatory requirements. Specialists from pharmaceutical companies, academia, and the U.S. Drug Regulatory Affairs agency address current and changing practices in industrial drug granulation production. Text, charts, figures, and photographs illustrate the pros and cons of diverse methods and technologies for accurately achieving strong bonding of particles in tablets and capsules.
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Drug Substance and Excipient Characterization
CRYSTAL PROPERTIES AND POLYMORPHISM
Binders and Solvents
FACTORS INFLUENCING BINDER EFFICIENCY
ExtrusionSpheronization as a Granulation Technique
Sizing of Granulation
Methods and Significance
Bioavailability and Granule Properties
Regulatory Issues in Granulation Processes
agglomerates atomization batch binder solution blade blend bowl bulk density characterization chopper cleaning compactor Dev Ind Pharm dicalcium phosphate disintegration dissolution dosage form droplet Drug Dev Ind drug substance effect energy equipment excipients extruder feed screw filters flow fluid bed granulation fluid bed processor fluidized bed force formulation friability gran granulation process granule growth high shear mixer impeller speed increase Int J Pharm lactose liquid addition liquid binder manufacturing mean granule mechanical method methylcellulose microcrystalline cellulose microwave milling mixing moisture content Niro Inc nozzle operation parameters pellets Pharm Sci Pharm Technol porosity povidone powder pregelatinized starch properties reduced roll speed roller compaction scale-up screen shear granulators sieve sieve analysis slugging solid solubility solvent spheres spheronization spray dryer spray drying spray-drying starch strength tablet technique temperature tensile strength vacuum deaeration viscosity wet granulation wet massing