Science of Synthesis: Houben-Weyl Methods of Molecular Transformations Vol. 16: Six-Membered Hetarenes with Two Identical Heteroatoms
Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in December 2003.
Mitä ihmiset sanovat - Kirjoita arvostelu
Yhtään arvostelua ei löytynyt.
Yoshifuji and S
Muita painoksia - Näytä kaikki
Abstr acetic AcOH Acta Acylation added dropwise addition afford alkyl Amidine Amidine Derivatives amines amino anhyd aqueous aromatic aryl benzene Bull Carbon carboxylic CHCl3 Chem Chim chloride chromatography silica gel cinnoline CO2Et collected by filtration compounds concd Condensation cooled Cyclization Dienophiles dimethyl dioxane dried MgSO4 electrophilic equiv ester Et2O ethanolic ethyl EtOAc EtOH evaporated extracted filtered Formation Fragments give the corresponding guanidine halogen heated Heinisch hetarene Heterocycl hydrazine hydrogen ketones MeOH Method mixture was stirred mmol N-Oxides N—C Bonds NaOH nitrile nitrogen nucleophilic nucleophilic substitution Oxidation Perkin Trans Pharm phthalazine potassium precipitate Product Class purified pyridazine pyrimidines quinazoline react reagents recrystallized reduced pressure reflux residue Ring-Closure Reactions salt Scheme silica gel sodium solid soln solvent stirred at rt Substituents substituted Sulfur temperature Tetrahedron Lett toluene treatment Variation washed with H2O yield